Center for Childhood Cancer Research Cell Therapy Program, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Address correspondence to: David M. Barrett, CCCR Cell Therapy Program, Children’s Hospital of Philadelphia, Oncology/BMT CTRB 3032, 3501 Civic Center Boulevard, Philadelphia, Pennsylvania 19104-4318, USA. Phone: 267.426.9740; Email: firstname.lastname@example.org.
First published April 15, 2019 - More info
Chimeric antigen receptor (CAR) T cells are an effective therapy for relapsed or refractory pediatric B cell leukemia. Analysis of the starting material, the T cells collected from the patient prior to CAR manufacture, reveals possible biomarkers of cells destined to perform poorly in patients. Long-term follow-up shows that long periods of B cell aplasia, a marker of in vivo CAR activity, are associated with longer remission but also a higher chance of antigen-negative relapse. The role of transplantation as consolidative therapy is unclear in this nonrandomized data, but clearly warrants further study.
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